Reversible impairment of renal function associated with enalapril in a diabetic patient.

Abstract

Acute renal failure and hyperkalemia due to angiotensin-converting enzyme inhibitors have been described in diabetic patients with other predisposing conditions. The case reported here involves a patient with type 1 diabetes mellitus, microalbuminuria and normal renal function who was treated with enalapril. Two years after initiation of this therapy, at a time when glycemic control was poor, he presented with symptomatic hyperkalemia and impaired renal function accompanied by hyporeninemic hypoaldosteronism. This case illustrates that reversible impairment of renal function and hyperkalemia can present after 2 years of treatment with angiotensin-converting enzyme inhibitors in patients with precipitating factors.

• Authors: M M Albareda, R Corcoy
• Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne (CMAJ) Vol. 159 Issue 10 Pg. 1279-81 (Nov 17 1998) ISSN: 0820-3946 [Print] Canada
• PMID: 9861226 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents
• Enalapril

Topics

• Acute Kidney Injury (chemically induced)
• Adult
• Angiotensin-Converting Enzyme Inhibitors (adverse effects)
• Antihypertensive Agents (adverse effects)
• Diabetes Mellitus, Type 1 (complications)
• Diabetic Nephropathies (complications)
• Enalapril (adverse effects)
• Humans
• Hyperkalemia (chemically induced)
• Hypertension (complications, drug therapy)
• Hypoaldosteronism (chemically induced)
• Male
• Precipitating Factors