[Correlation in Staphylococcus aureus infections between toxic shock syndrome toxin-1 production and clinical feature].

Abstract

Toxic shock syndrome (TSS) is caussed by toxic shock syndrome toxin-1 (TSST-1) of Staphylococcus aureus. We studied the incidence of TSST-1 production by the clinical isolates of S. aureus, in order to clarify the possibility of TSS caused by S. aureus. One hundred and seventeen clinical isolates of S. aureus were tested. Of 117 strains, 74 were methicillin-cephem resistant S. aureus (MRSA), and 43 were methicillin-cephem sensitive S. aureus (MSSA). TSST-1 production and penicillinase (PCase) activity were measured by means of reversed passive Latex aggulutination method and acidmetric assay, respectively. The incidences of TSST-1 production by PCase positive MRSA, PCase negative MRSA, PCase positive MSSA and PCase negative MSSA were 92% (55/60), 78% (11/14), 21% (7/33) and 0% (0/10), respectively. TSS occurred in a patient with chronic complicated pyelonephritis after endopyelotomy for hydronephrosis. In this patient, PCase positive MRSA which produced TSST-1 was isolated from urinary tract, and he was cured after administration of arbekacin. These results indicsate that methicillin-cephem resistance and PCase production are the risk factors for TSST-1 production in S. aureus.

• Authors: H Kiyota, Y Ohishi, S Onodera, K Miki, M Ueda
• Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 72 Issue 6 Pg. 593-8 (Jun 1998) ISSN: 0387-5911 [Print] Japan
• PMID: 9695469 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bacterial Toxins
• Enterotoxins
• Superantigens
• enterotoxin F, Staphylococcal
• Penicillinase

Topics

• Bacterial Toxins
• Enterotoxins (biosynthesis)
• Humans
• Methicillin Resistance
• Penicillinase (biosynthesis)
• Shock, Septic (physiopathology)
• Staphylococcal Infections (physiopathology)
• Staphylococcus aureus (metabolism)
• Superantigens