Abstract | PURPOSE: PATIENT: A 31-week-old girl born prematurely to a G2POA1 mother was noted to have thrombocytopenia which lasted 18 days without any evidence of infection. MATERIALS AND METHODS: RESULTS: Both mother and infant were positive for HPA-1 (PL(A1)) antigens. The mother's HLA phenotype was A3, A31, B7, B27. The level of platelet-associated IgG was not increased on maternal platelets; however, increased platelet-associated IgG was detected on the infant's platelets. Antibodies to platelet glycoproteins HPA1 to 5 were not detectable in the maternal plasma. Maternal serum was positive for anti-HLA antibodies, which reacted to 23 of 27 panel cells. The presence of HLA antibodies was confirmed by enzyme-linked immunoassay. Of note, the maternal antibodies reacted positively to the infant's platelets and anti-IgG anti-HLA antibodies were detected in the serum sample from the infant collected at birth. When the activity and IgG subclass of the maternal anti-HLA antibodies were compared with those of other mothers known to have high anti-HLA antibody activity, no differences were noted. CONCLUSION: This report documents a patient with neonatal thrombocytopenia induced by maternal IgG anti-HLA antibody. Neither activity nor IgG subclass could explain the occurrence of NAIT. The factors that contribute to NAIT induced by maternal anti-HLA antibodies remain to be identified.
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Authors | M L del Rosario, E R Fox, T S Kickler, K J Kao |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
1998 May-Jun
Vol. 20
Issue 3
Pg. 252-6
ISSN: 1077-4114 [Print] United States |
PMID | 9628438
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antigens, Human Platelet
- HLA Antigens
- Immunoglobulin G
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Topics |
- Adult
- Antigens, Human Platelet
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fetomaternal Transfusion
(immunology)
- HLA Antigens
(immunology)
- Humans
- Immunoglobulin G
(blood)
- Infant, Newborn
- Infant, Newborn, Diseases
(immunology)
- Platelet Count
- Pregnancy
- Thrombocytopenia
(immunology)
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