Malignant histiocytosis: complete remission with combination chemotherapy.

Abstract

A case of a 16-year-old girl with malignant histiocytosis involving the lymph nodes, bone marrow, peripheral blood, liver, and spleen is described. This patient achieved a complete remission with cyclic quadruple chemotherapy consisting of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP). She is alive and free of disease more than 4 years after the completion of COPP and after having had maintenance treatment with a small dose of cyclophosphamide for 2 3/4 years. Such good results with the COPP regimen in malignant histiocytosis have not been reported previously, and it is suggested that this modality of treatment warrants further trial.

• Authors: R S Stein, E M Moran, G E Byrne Jr
• Journal: Cancer (Cancer) Vol. 38 Issue 3 Pg. 1083-6 (Sep 1976) ISSN: 0008-543X [Print] United States
• PMID: 953957 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Procarbazine
• Vincristine
• Cyclophosphamide
• Prednisone

Topics

• Adolescent
• Cyclophosphamide (administration & dosage)
• Drug Therapy, Combination
• Female
• Humans
• Lymphatic Diseases (drug therapy, pathology)
• Prednisone (administration & dosage)
• Procarbazine (administration & dosage)
• Remission, Spontaneous
• Vincristine (administration & dosage)