Alveolar lipoproteinosis in lung allograft recipients.

Abstract

Three cases of pulmonary alveolar proteinosis developing in lung allograft recipients are reported. In each case, repeated bouts of alveolar damage from harvest/reperfusion injury, rejection, and infection were observed before the development of intraalveolar accumulation of granular, periodic acid-Schiff-positive material in the allograft lungs. It is speculated that iatrogenic immunosuppression combined with defective clearance of alveolar material by alveolar macrophages created a milieu conducive to the accumulation of surfactant, lipoprotein, and fibrinous debris that was morphologically identical to alveolar proteinosis.

• Authors: S A Yousem
• Journal: Human pathology (Hum Pathol) Vol. 28 Issue 12 Pg. 1383-6 (Dec 1997) ISSN: 0046-8177 [Print] United States
• PMID: 9416695 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Eisenmenger Complex (complications, surgery)
• Female
• Heart Septal Defects, Atrial (complications, surgery)
• Heart-Lung Transplantation (adverse effects, pathology)
• Humans
• Hypertension, Pulmonary (complications, surgery)
• Lung Diseases, Interstitial (complications, surgery)
• Lung Transplantation (adverse effects, pathology)
• Male
• Middle Aged
• Pulmonary Alveolar Proteinosis (etiology, pathology)
• Transplantation, Homologous