Abstract | BACKGROUND & AIMS: METHODS: Experiments were performed in esophageal smooth muscle cells (ESO) isolated by enzymatic digestion from the circular layer of normal and esophagitis animals. Content of peptidoleukotrienes ( leukotriene [LT] C4, LTD4, and LTE4) was measured in esophageal circular muscle tissue. RESULTS: CONCLUSIONS:
Esophagitis shifts the signal transduction pathway activated by ACh. Esophagitis increased the contribution of secreted PLA2 and of LTs to ACh-induced contraction.
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Authors | N Kim, U D Sohn, V Mangannan, H Rich, M K Jain, J Behar, P Biancani |
Journal | Gastroenterology
(Gastroenterology)
Vol. 112
Issue 5
Pg. 1548-58
(May 1997)
ISSN: 0016-5085 [Print] United States |
PMID | 9136833
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Diglycerides
- Indazoles
- Leukotrienes
- ICI 198615
- Arachidonic Acid
- Phospholipases A
- Phospholipases A2
- Acetylcholine
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Topics |
- Acetylcholine
(pharmacology)
- Animals
- Arachidonic Acid
(metabolism)
- Cats
- Diglycerides
(pharmacology)
- Drug Synergism
- Esophagitis
(physiopathology)
- Esophagus
(drug effects)
- Female
- Indazoles
(pharmacology)
- Leukotrienes
(physiology)
- Male
- Muscle Contraction
(drug effects)
- Muscle, Smooth
(drug effects)
- Phospholipases A
(physiology)
- Phospholipases A2
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