Treatment of genital HPV infection with carbon dioxide laser and systemic interferon alpha-2b.

Abstract

BACKGROUND AND OBJECTIVES:

Treatment of genital warts is problematic. Numerous treatment modalities are available, but response to any therapy often is unsatisfactory. Recently, studies have suggested that interferons would be effective in the treatment of some genital warts.

GOAL OF THIS STUDY:

To compare carbon dioxide laser with or without adjuvant subcutaneously administered interferon alpha-2b in the treatment of genital human papillomavirus infection.

STUDY DESIGN:

One hundred randomized women with genital HPV infection were treated with carbon dioxide laser and adjuvant systemic interferon alpha-2b or carbon dioxide laser and placebo. Patients were followed colposcopically, cytologically, and by HPV DNA testing for 6 months.

RESULTS:

Complete response was seen in 62% patients who received adjuvant interferon, and in 68% patients who received placebo. However, recurrence was less common in patients treated with interferon who were infected with HPV 16/18.

CONCLUSION:

Only a subgroup of patients, women infected with HPV DNA 16/18, benefited from adjuvant systemic interferon treatment.

• Authors: P Nieminen, M Aho, M Lehtinen, E Vesterinen, A Vaheri, J Paavonen
• Journal: Sexually transmitted diseases (Sex Transm Dis) 1994 Mar-Apr Vol. 21 Issue 2 Pg. 65-9 ISSN: 0148-5717 [Print] United States
• PMID: 9071414 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adolescent
• Adult
• Antiviral Agents (therapeutic use)
• Combined Modality Therapy
• Condylomata Acuminata (therapy, virology)
• Double-Blind Method
• Female
• Humans
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Laser Therapy
• Middle Aged
• Papillomaviridae (classification)
• Recombinant Proteins
• Recurrence
• Treatment Outcome
• Uterine Cervical Diseases (therapy, virology)
• Vaginal Diseases (therapy, virology)
• Vulvar Diseases (therapy, virology)