Is a (n inborn) deficiency of prostacyclin synthesis stimulating plasma factor associated with increased lipoprotein(a)?

Abstract

Patients with the antiphospholipid syndrome as well as those with a lack in the prostacyclin synthesis stimulating plasma factor (PF) are prone to develop thrombophilia and are at a higher clinical risk for vascular disease. As patients with the antiphospholipid syndrome have been reported to show elevated lipoprotein (Lp)(a) levels, we re-examined all our patients known to have an inborn or an acquired persistent deficiency of PF. Their non-affected relatives served as controls. In addition, 36 patients suffering from clinically manifested atherosclerosis as well as 16 healthy adults, all of them having elevated Lp(a) levels (> 30 mg/dl), were screened for a PF deficiency. In fact, all the patients with a deficient PF activity showed elevated Lp(a) values. While the prevalence of PF deficiency ranges about 1-2%, in 7 (19%) patients with clinically manifested atherosclerosis and 3 (19%) healthy adults with elevated Lp(a) this defect was found. The findings demonstrate an association between PF deficiency and Lp(a), indicating a biochemical interaction which needs to be further elucidated.

• Authors: H Kritz, J Pidlich, J O'Grady, H Sinzinger
• Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 55 Issue 5 Pg. 363-72 (Nov 1996) ISSN: 0952-3278 [Print] Scotland
• PMID: 8981634 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biological Factors
• Lipids
• Lipoprotein(a)
• Protein C
• Protein S
• prostacyclin synthesis stimulating plasma factor
• Antithrombin III

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Antithrombin III (analysis)
• Arteriosclerosis (genetics, metabolism)
• Biological Factors (blood, deficiency, metabolism)
• Case-Control Studies
• Child
• Female
• Follow-Up Studies
• Humans
• Lipid Metabolism
• Lipids (blood)
• Lipoprotein(a) (blood)
• Male
• Metabolism, Inborn Errors (genetics, metabolism)
• Middle Aged
• Pedigree
• Protein C (analysis)
• Protein S (analysis)