Controlled study of cytolethal distending toxin-producing Escherichia coli infections in Bangladeshi children.

Abstract

The role of cytolethal distending toxin (CDT)-producing Escherichia coli, a newly described category of E. coli, in the causation of diarrhea was studied by screening E. coli isolates from 546 children < 5 years of age with diarrhea and 215 matched controls without diarrhea by using a specific DNA probe. Although CDT-positive E. coli strains were isolated from more children with diarrhea than from healthy controls (3.1 versus 0.93%), this difference did not reach statistical significance (P = 0.082). All CDT-positive strains also possessed the virulence factors of enteropathogenic E. coli or enteroaggregative E. coli isolates.

• Authors: M J Albert, S M Faruque, A S Faruque, K A Bettelheim, P K Neogi, N A Bhuiyan, J B Kaper
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 34 Issue 3 Pg. 717-9 (Mar 1996) ISSN: 0095-1137 [Print] United States
• PMID: 8904444 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bacterial Toxins
• cytolethal distending toxin

Topics

• Acute Disease
• Bacterial Toxins (analysis)
• Child, Preschool
• Diarrhea (etiology)
• Escherichia coli (pathogenicity)
• Escherichia coli Infections (etiology)
• Feces (microbiology)
• Humans
• Infant