Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer.

Abstract

BACKGROUND & AIMS:

Omeprazole is less effective in healthy subjects than in patients with duodenal ulcers. The aim of this study was to determine whether Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcers.

METHODS:

In 16 patients with duodenal ulcers, baseline intragastric acidity was measured before and 4-6 weeks after the cure of H. pylori infection. In 17 patients with duodenal ulcers, 24-hour pH metry was performed during treatment with 20 mg omeprazole once daily before as well as after eradication of H. pylori. Intragastric acidity was measured using a glass electrode placed 5 cm below the cardia. H. pylori infection was assessed by [13C] urea breath test, culture, histology, and rapid urease test.

RESULTS:

H. pylori eradication resulted in marked decrease of the pH-increasing effect of omeprazole (24-hour median gastric pH, 5.5 vs. 3.0; P<0.002) that was most pronounced during nighttime (median gastric pH, 6.4 vs. 2.1; P=0.001). On the other hand, baseline intragastric pH remained unchanged after eradication (median gastric pH, 1.0 vs. 1.1; P=0.5).

CONCLUSIONS:

In patients with duodenal ulcers treated with omeprazole, intragastric pH depends significantly on the presence or absence of H. pylori, whereas baseline pH remained unchanged after H. pylori eradication.

• Authors: J Labenz, B Tillenburg, U Peitz, J P Idström, E F Verdú, M Stolte, G Börsch, A L Blum
• Journal: Gastroenterology (Gastroenterology) Vol. 110 Issue 3 Pg. 725-32 (Mar 1996) ISSN: 0016-5085 [Print] United States
• PMID: 8608881 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Omeprazole

Topics

• Adult
• Aged
• Anti-Ulcer Agents (therapeutic use)
• Duodenal Ulcer (drug therapy, etiology, metabolism)
• Female
• Gastric Acid (metabolism)
• Gastric Acidity Determination
• Gastritis (etiology)
• Helicobacter Infections (complications, drug therapy)
• Helicobacter pylori (physiology)
• Humans
• Hydrogen-Ion Concentration
• Male
• Middle Aged
• Omeprazole (therapeutic use)