Effect of ascorbic acid 2-0-alpha-glucoside on hydrocortisone-induced cataract formation in developing chick embryos: I. Comparison of the preventive effect of ascorbic acid derivatives.

Abstract

The effect of ascorbic acid 2-O-alpha-glucoside (AA-2G) on hydrocortisone (HC)-induced lens opacity in developing chick embryo was examined and compared with those of ascorbic acid (AsA) and ascorbic acid 2-phosphate (AA-2P). The opacity was dose-dependently inhibited by a single administration of 10 or 20 mumol/egg of AA-2G and by three repeated administrations of 1, 3 or 10 mumol/egg of AA-2G. AA-2G was the most effective among the three compounds. Glucose did not enhance the preventive effect of AsA against HC-induced opacity, and neither dehydro ascorbic acid nor glucose also prevented HC-induced cataract. In the histological study, we observed many small vacuoles in the nuclear region of the opaque lens treated with HC. AA-2G inhibited the formation of such vacuoles, an effect closely correlated with the prevention of cataract formation.

• Authors: M Nagata, H Tanioka, H Mibu, M Hikida, M Akiba, I Yamamoto
• Journal: Journal of ocular pharmacology (J Ocul Pharmacol) Vol. 9 Issue 1 Pg. 59-68 ( 1993) ISSN: 8756-3320 [Print] United States
• PMID: 8463733 (Publication Type: Comparative Study, Journal Article)

Chemical References

• ascorbate-2-phosphate
• ascorbic acid 2-O-glucoside
• Ascorbic Acid
• Hydrocortisone

Topics

• Animals
• Ascorbic Acid (administration & dosage, analogs & derivatives, pharmacology)
• Cataract (chemically induced, pathology, prevention & control)
• Chick Embryo
• Dose-Response Relationship, Drug
• Hydrocortisone
• Lens, Crystalline (drug effects, pathology)
• Vacuoles (drug effects)