Abstract |
To examine the role of brain natriuretic peptide (BNP) in acute myocardial infarction (AMI), we measured the plasma concentration of immunoreactive (ir) BNP together with that of atrial natriuretic peptide ( ANP) over the 4-week course of AMI in 16 patients treated with early coronary angioplasty. Both the plasma ir- ANP and ir-BNP levels were increased on the first day of the infarction compared with the values in normal subjects. During the clinical course of the infarction, the plasma ir- ANP concentration soon decreased, while the plasma ir-BNP level remained elevated at 2 weeks after the infarction, also exhibiting a high level at 4 weeks. Plasma ir-BNP levels on day 1 or days 14 and 28 were inversely correlated with left ventricular ejection fraction obtained by left ventriculography at the acute or chronic phase, respectively. Plasma ir-BNP concentrations on days 14 and 28 were positively correlated with the maximal myosin light chain I level, an indicator of infarct size. These observations suggest that the plasma ir-BNP level increased to compensate for the ventricular dysfunction associated with the size of the infarct in AMI. BNP may act as a cardiac hormone in AMI, differing somewhat from ANP in its synthetic, secretory, or clearance behavior.
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Authors | T Horio, K Shimada, M Kohno, T Yoshimura, T Kawarabayashi, K Yasunari, K Murakawa, K Yokokawa, M Ikeda, T Fukui |
Journal | American heart journal
(Am Heart J)
Vol. 126
Issue 2
Pg. 293-9
(Aug 1993)
ISSN: 0002-8703 [Print] United States |
PMID | 8337997
(Publication Type: Journal Article)
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Chemical References |
- Nerve Tissue Proteins
- Natriuretic Peptide, Brain
- Atrial Natriuretic Factor
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Topics |
- Angioplasty, Balloon, Coronary
- Atrial Natriuretic Factor
(blood, metabolism)
- Cardiac Catheterization
- Female
- Hemodynamics
(physiology)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnosis, metabolism, therapy)
- Natriuretic Peptide, Brain
- Nerve Tissue Proteins
(blood, metabolism, physiology)
- Radioimmunoassay
- Time Factors
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