Abstract |
To evaluate the efficacy of glucocorticoids in the treatment of infants with meconium aspiration syndrome, a double-blind study using hydrocortisone or a lactose placebo was undertaken. Thirty-five infants were included in the study. No significant differences in arterial Po2, Pco2, pH, A-aDo2 gradients, in requirement for assisted ventilation, or in survival were domonstrated between the groups. In control infants, a significant decrease (p less than 0.01) in respiratory distress score was found at 48 to 72 hours of age; in treated infants, it was seen only after 72 hours. The infants in the treated group took a significantly longer (p less than 0.01) period of time to wean to room air than those in the control group (68.9 +/- 9.6 hours vs 36.6 +/- 6.9 hours). On the basis of these observations, hydrocortisone is not recommended for treatment of MAS.
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Authors | T F Yeh, G Srinivasan, V Harris, R S Pildes |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 90
Issue 1
Pg. 140-3
(Jan 1977)
ISSN: 0022-3476 [Print] United States |
PMID | 830880
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Drug Evaluation
- Humans
- Hydrocortisone
(therapeutic use)
- Infant, Newborn
- Meconium
- Placebos
- Pneumonia, Aspiration
(drug therapy)
- Respiratory Distress Syndrome, Newborn
(drug therapy)
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