Abstract |
To examine the role of delta-opioid receptors in the regulation of the sympathoadrenomedullary system, the effects of the highly selective delta-opioid receptor agonist deltorphin (DT) on plasma catecholamine responses to insulin-induced hypoglycemia (IIH) and cold pressor test ( CPT) have been investigated in normal subjects in two separate studies. DT failed to modify basal plasma levels of both norepinephrine (NE) and epinephrine (E). DT completely suppressed the IIH-evoked elevation of NE, whereas it attenuated the E response by 20%, with the DT-induced decrease in E release failing to achieve statistical significance. DT completely blocked the release of both NE and E elicited by CPT. We conclude that specific delta-opioid receptor stimulation exerts an inhibitory effect on NE release induced by both IIH and CPT. These findings provide evidence that delta-opioid receptors may influence the autonomic sympathetic reactivity.
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Authors | E C degli Uberti, M R Ambrosio, L Vergnani, F Portaluppi, M Bondanelli, G Trasforini, A Margutti, S Salvadori |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 77
Issue 6
Pg. 1490-4
(Dec 1993)
ISSN: 0021-972X [Print] United States |
PMID | 8263131
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Oligopeptides
- Receptors, Opioid, delta
- deltorphin
- Norepinephrine
- Epinephrine
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Topics |
- Adult
- Blood Pressure
(drug effects)
- Epinephrine
(blood)
- Heart Rate
(drug effects)
- Humans
- Male
- Norepinephrine
(blood)
- Oligopeptides
(pharmacology)
- Receptors, Opioid, delta
(drug effects, physiology)
- Stress, Physiological
(physiopathology)
- Sympathetic Nervous System
(drug effects, physiology)
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