Serum proline imino-peptidase activity in normal adult subjects and in patients with Paget's disease of bone.

Abstract

The activity of proline imino-peptidase (EC 3.4.1.4) may provide a measure of collagen degradation, and a method for its estimation in human serum is described. The mean value of this enzyme activity in 48 normal adults of 4.7 mU/l (S.D. 0.9) did not change with sex, age or dietary collagen. In 8 patients with liver disease associated with elevated levels of plasma alkaline phosphatase activity the mean value was normal (4.5 mU/l, S.D. 1.5). However, in 25 patients with untreated Paget's disease of bone, values were significantly increased (mean 7.4 mU/l; S.D. 2.8; p less than 0.001) and were positively correlated with plasma alkaline phosphatase activity (r = 0.75; p less than 0.001) and with urine total hydroxyproline excretion (r = 0.68; p less than 0.001). In patients given disodium ethane-1-hydroxy-1,1-diphosphonate for 3--6 months, serum proline imino-peptidase activity decreased to normal values.

• Authors: J Whiteley, M J Francis, R J Walton, R Smith
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 71 Issue 2 Pg. 157-63 (Sep 06 1976) ISSN: 0009-8981 [Print] Netherlands
• PMID: 822968 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Proteins
• Gelatin
• Proline
• Alkaline Phosphatase
• Aminopeptidases
• Etidronic Acid
• Hydroxyproline

Topics

• Adult
• Aged
• Alkaline Phosphatase (blood)
• Aminopeptidases (blood)
• Dietary Proteins (metabolism)
• Etidronic Acid (therapeutic use)
• Female
• Gelatin (metabolism)
• Humans
• Hydroxyproline (urine)
• Liver Diseases (enzymology)
• Male
• Middle Aged
• Osteitis Deformans (enzymology)
• Proline