Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice.

Abstract

Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T1/2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A/J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 micrograms/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 micrograms/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.

• Authors: S Nesnow, A Gold, R Sangaiah, T J Slaga
• Journal: Cancer letters (Cancer Lett) Vol. 73 Issue 2-3 Pg. 73-6 (Sep 30 1993) ISSN: 0304-3835 [Print] Ireland
• PMID: 8221632 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Mutagens
• Pyrenes
• cyclopenta(c,d)pyrene
• Benzo(a)pyrene
• Methylcholanthrene
• benz(j)aceanthrylene

Topics

• Animals
• Benzo(a)pyrene
• Carcinogens
• Dose-Response Relationship, Drug
• Female
• Methylcholanthrene (analogs & derivatives)
• Mice
• Mutagens
• Papilloma (chemically induced)
• Pyrenes
• Skin Neoplasms (chemically induced)