[Hypokalemic quadriplegia revealing Fanconi syndrome and myeloma].

Abstract

The authors report a case of multiple myeloma presenting in an unusual fashion as a hypokalaemic quadriparesis secondary to a renal proximal tubulopathy. The tubular functional disturbance appeared to be related to the presence of kappa-type light chains. Electron microscopical study demonstrated in the cells of the concoluted tubules abnormalities which apparently constitute the anatomical substratum of this abnormality. Study of tubular function revealed glycosuria, proximal type tubular acidosis and altered reabsorption of phophorus and uric acid.

• Authors: A Fournier, J F Bernaudin, J Kremski, G Hirbec, J P Berry, G Lagrue, J Hazard
• Journal: La Nouvelle presse medicale (Nouv Presse Med) Vol. 4 Issue 42 Pg. 2983-6 (Dec 06 1975) ISSN: 0301-1518 [Print] France
• Vernacular Title: Quadriparésie hypokaliémique révélatric d'un syndrome de Fanconi et d'un myélome
• PMID: 815883 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunoglobulin kappa-Chains
• Bence Jones Protein
• Potassium

Topics

• Acidosis, Renal Tubular (etiology)
• Bence Jones Protein
• Humans
• Hypokalemia (complications)
• Immunoglobulin kappa-Chains
• Kidney Tubules, Proximal (ultrastructure)
• Male
• Middle Aged
• Multiple Myeloma (complications, pathology)
• Potassium (urine)
• Quadriplegia (etiology)