Glycosuria

The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).

Networked: 1156 relevant articles (59 outcomes, 63 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Polyuria
2.	Hyperglycemia
3.	Polydipsia
4.	Proteinuria
5.	Body Weight (Weight, Body)

Experts

1.	Ferrannini, Ele: 9 articles (11/2023 - 05/2013)
2.	Baldi, Simona: 5 articles (11/2023 - 02/2014)
3.	Sahebkar, Amirhossein: 5 articles (06/2023 - 01/2019)
4.	Yaribeygi, Habib: 5 articles (06/2023 - 01/2019)
5.	Nishiyama, Akira: 4 articles (07/2020 - 12/2015)
6.	Lawlor, Debbie A: 4 articles (01/2020 - 04/2004)
7.	Muscelli, Elza: 4 articles (01/2017 - 02/2014)
8.	de Leiva-Hidalgo, Alberto: 3 articles (11/2023 - 12/2022)
9.	de Leiva-Pérez, Alejandra: 3 articles (11/2023 - 12/2022)
10.	Chhabra, Kavaljit H: 3 articles (09/2023 - 03/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glycosuria:

1.	Glucose (Dextrose)FDA LinkGeneric 01/01/1984 - "In the first instance, a significant improvement both in the plasma glucose levels, as well as in the daily glucose profile and glycosuria was observed. " 10/01/2017 - "Overall, we show that renal-denervated WT and diabetic mice recapitulate the phenotype of improved glucose tolerance and elevated glycosuria associated with reduced renal GLUT2 levels observed in obese ArcPomc-/- mice. " 10/01/2017 - "We demonstrated previously that their improved glucose tolerance is due to elevated glycosuria. " 09/01/1982 - "On the alternative program, control improved markedly in 23 of the 25 patients, as evidenced by lower fasting serum glucose concentrations and decreased glycosuria. " 01/01/1980 - "A further HbAI decrease was observed until day 60 following Biostator treatment, during which period glycaemic control improved, as assessed by fasting and post-lunch plasma glucose values and daily glycosuria determined every 10 days. "
2.	Insulin (Novolin)FDA Link 02/01/1982 - "These findings indicate that insulin treatment (sufficient to reduce daily glycosuria) applied during the overtly diabetic period markedly improved the recovery of the insulin stores in the pancreas. " 06/01/1989 - "The present study involved treating BB diabetic rats with a low (hyperglycemic) and high (normoglycemic) insulin dose for 12 weeks after the detection of glycosuria. " 01/01/2008 - "Plasma insulin concentrations and glycosuria were determined. " 02/01/2005 - "Plasma insulin concentrations and glycosuria were determined. " 09/01/2004 - "Plasma insulin concentrations and glycosuria were determined. "
3.	Blood Glucose (Blood Sugar)IBA 04/15/2004 - "Our study suggests that glycosuria is not only dependent on the blood glucose level, but highly influenced by diastolic blood pressure. " 01/01/2001 - "The side effects of higher blood sugar levels and glycosuria were found in the 2 trials where these were sought. " 01/01/2000 - "The side effects of higher blood sugar levels and glycosuria were found in the 2 trials where these were sought. " 05/01/1991 - "Laboratory studies showed raised ESR, 4+ glycosuria, and a blood sugar of 351mg/dl. " 01/01/2018 - "Occurrence of glycosuria ≥1+ is an indication to test blood glucose."
4.	Sodium-Glucose Transporter 2 InhibitorsIBA 02/01/2024 - "Role of Glycosuria in SGLT2 Inhibitor-Induced Cardiorenal Protection: A Mechanistic Analysis of the CREDENCE Trial." 02/01/2023 - "Ongoing efforts to clarify the exact mechanisms of action of SGLT2 inhibitors (SGLT2i) reveal that glycosuria and osmotic diuresis, resulting from the blockade of renal receptors, is not the sole pathophysiological mechanism. " 01/01/2021 - "SGLT2-inhibitors; more than just glycosuria and diuresis." 01/13/2020 - "The benefit from SGLT2 inhibitors stems from its main mechanism of action, which occurs in the proximal tubule of the nephron, causing glycosuria, and a consequent increase in natriuresis. " 01/01/2017 - "A major mode of action of SGLT2 inhibitors appears to be 'glycosuria' and 'natriuresis,' leading to amelioration of systemic glycemic homeostasis and potential cardio-renal protection. "
5.	Triglycerides (Triacylglycerol)IBA 01/01/1983 - "The levels of glycosylated hemoglobin (Hb AI), intermittent glycemia and glycosuria over 24 hr, Mw index, fasting serum cholesterol and triglycerides, and 24-hr proteinuria were determined in 20 healthy subjects and 88 diabetics representing different clinical types of diabetes mellitus. " 10/01/1985 - "Glycosuria was eliminated, and mean 24-h plasma glucose and hemoglobin A1c levels decreased in both patients and remained in or near the normal range for 3 yr. Improvements were also noted in serum triglyceride concentrations and vitreous fluorescein concentrations after iv fluorescein injection. " 06/01/2000 - "Insulin 1) reduces glycosuria and its caloric expenditure; 2) stimulates the stockage of fatty acids into triglycerides in adipose tissue, thus favoring an increase in adipose mass; 3) yields a positive nitrogen balance through an inhibition of muscle proteolysis, thus favoring an increase in lean mass. " 02/01/1988 - "There were no differences in fasting, one-, two-, and three-hour post-lunch serum glucose levels; 24-hour glycosuria; glycohemoglobin levels; fasting and postprandial serum triglyceride levels, or fasting high-density lipoprotein-cholesterol levels. " 01/01/2007 - "Caffeine significantly reduced body weight and glycosuria (weeks 2-9), improved glucose tolerance (week 9), had no effect on elevated plasma triglycerides, plasma cholesterol (week 9) and blood pressure (week 9), and significantly increased plasma cholesterol level (weeks 5 and 9). "
6.	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 09/27/1993 - "The area under the relative operating characteristic curve was significantly greater for glycated hemoglobin than for either measure of glycosuria. " 01/01/2023 - "Glycosuria without elevated glycated Hemoglobin occurred. " 01/01/1996 - "Fasting and post-prandial glycemia and insulinemia as well as glycosuria were weekly analysed during the sixty days preceding glycosylated hemoglobin (HbA1c), fructosamines and serum scavenging capacity determination. " 09/27/1993 - "Glycated hemoglobin, quantitative glycosuria, and dipstick glycosuria were compared in 237 nonfasting subjects. " 02/01/1991 - "The majority of the known diabetics exhibited glycosuria and elevated glycohemoglobin levels, indicating poor control. "
7.	CarbohydratesIBA 08/01/1980 - "No significant reduction in glycosuria was seen in the 10 studies on lower carbohydrate intakes. " 08/01/1980 - "Where carbohydrate formed more than 40% of the calorie intake, there was a mean 64% reduction in glycosuria over the last 2 days on guar (P < 0.001, 14 studies, 11 patients). " 01/01/2016 - "We conclude that by shunting substantial amounts of carbohydrate into urine, SGLT2-mediated glycosuria results in a progressive shift in fuel utilization toward fatty substrates. " 01/01/2006 - "Allen's case histories shows that a 70% fat, 8% carbohydrate diet could eliminate glycosuria among hospitalized patients. " 11/01/2002 - "Carbohydrate storage was calculated as ingested carbohydrate - (postprandial glycosuria + suprabasal postprandial carbohydrate oxidation). "
8.	Uric Acid (Urate)IBA 12/06/1975 - "Study of tubular function revealed glycosuria, proximal type tubular acidosis and altered reabsorption of phophorus and uric acid." 01/15/2015 - "Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus." 10/01/2014 - "In contrast, diabetic patients with glycosuria had a null prevalence of hyperuricemia and excreted more uric acid and Na than diabetic subjects without glycosuria. " 10/01/2014 - "Of note, diabetic subjects with glycosuria, who represented 24% of the diabetic participants, had a null prevalence of hyperuricemia, and statistically higher values for fractional excretion of uric acid, Na excretion index, and prevalence of microalbuminuria than those without glycosuria. " 01/01/1992 - "We found no correlation between the fractional excretion of uric acid and the degree of glycosuria in IDDM patients. "
9.	empagliflozinIBA 01/01/2018 - "Empagliflozin ameliorates kidney injury in type 2 diabetic female mice by promoting glycosuria, and possibly by reducing systemic and renal artery stiffness, and reversing RECK suppression." 01/01/2021 - "This suggests that empagliflozin stimulates osmotic diuresis through increased glycosuria rather than natriuresis in patients with acute HF." 01/01/2020 - "Although the patient did not take empagliflozin the day of surgery, the drug has a half-life of >12 hours, and other reports have described continued glycosuria for up to 10 days after drug discontinuation. " 04/01/2016 - "Empagliflozin induced similar glycosuria and metabolic and hormonal responses in Met and TN patients. " 02/01/2014 - "Both single-dose and chronic empagliflozin treatment caused glycosuria during fasting (median, 7.8 [interquartile range {IQR}, 4.4] g/3 hours and 9.2 [IQR, 5.2] g/3 hours) and after meal ingestion (median, 29.0 [IQR, 12.5] g/5 hours and 28.2 [IQR, 15.4] g/5 hours). "
10.	Hemoglobins (Hemoglobin)IBA 01/01/1989 - "A considerable improvement in metabolic regulation was attained which led to the reduction in glycemia level on an empty stomach and after the meal, to the reduction or elimination of glycosuria and to the significant decrease in glycolized hemoglobin. " 03/01/2012 - "Case 1: a 4-yr-old girl referred for glycosuria presented hemoglobin A1c (HbA1c) of 6.6%. " 09/29/2015 - "We observed combinations of pregnancy complications that predict high risk of death and 2 new risk markers, glycosuria and hemoglobin decline. " 06/01/1984 - "Urinary NAG increases more rapidly than hemoglobin A1 after onset of hyperglycemia and glycosuria.(ABSTRACT TRUNCATED AT 250 WORDS)" 09/29/2015 - "Preexisting hypertension (hazard ratio, 3.5; 95% confidence interval, 2.4-5.1); glycosuria (hazard ratio, 4.2; confidence interval, 1.3-13.1); late-onset preeclampsia (after week 34, hazard ratio, 2.0; confidence interval, 1.2-3.5); and hemoglobin decline over the second and third trimesters (hazard ratio, 1.7; confidence interval, 1.2-2.7) predicted CVD death. "

Therapies and Procedures

1.	Therapeutics 04/01/1991 - "Similarly glycosuria did not show significative increment during the test with both beta-blocking therapies. " 03/01/1979 - "Closer examination revealed that factors such as therapy and glycosuria affected the results of these tests. " 10/01/2005 - "Menstrual irregularities, amenorrhoea, azoospermia, rise in blood pressure and glycosuria were the major side-effects seen during DCP pulse therapy. " 01/01/1996 - "Fourteen patients intermittently displayed variable degrees of glycosuria, phosphaturia, and/or proteinuria during IFX therapy. " 01/01/1986 - "IDDM, glycosuria and hyperglycemia developed in 0/22 rats followed up to 370 days of age (up to 210 days following the cessation of CsA therapy); histologic examination of their islets was normal. "
2.	Glycemic Control 07/01/1980 - "The results of this study suggest that (1) although there is a positive correlation between GlHb and FPG, the two tests cannot be used interchangeably in the evaluation of diabetic control; and (2) in the majority of the patients the absence of glycosuria tends to create the false assurance of satisfactory blood glucose control." 04/03/2017 - "Inhibiting these transporters has been shown to effectively improve glycemic control through inducing glycosuria and is generally well tolerated, although patients experience more genital infections. " 02/17/2023 - "By contrasting glucose reabsorption in the proximal convoluted tubule of the nephron, SGLT2 inhibition results in glycosuria with improved glycemic control. " 01/01/2016 - "The mutations, which in vitro affected glucose transport in a cell line model, and the ensuing glycosuria were not associated with better glycemic control during a follow-up period of more than 10 years. " 01/01/2004 - "We examined whether the finding of glycosuria and its level in themselves give information of clinical relevance, apart from being an unreliable indicator of glycemic control. "
3.	Pancreatectomy 10/01/2008 - "Predictive value of postoperative glycosuria after partial elective pancreatectomy in focal congenital hyperinsulinism." 03/20/1982 - "Dragstedt reported that the amount of insulin required to control glycosuria after partial pancreatectomy is much greater than that needed after total pancreatectomy. " 01/01/2014 - "Original studies conducted in experimental animals with the nonspecific SGLT inhibitor phlorizin showed that hyperglycemia after pancreatectomy decreased as a result of forced glycosuria. " 01/01/1988 - "Glycosuria and kidney weight were significantly reduced by subtotal pancreatectomy, although creatinine clearance and blood glucose levels were not different from diabetic controls. " 12/01/2017 - "Paulescu analysed the clinical and biochemical alterations in diabetic patients and in dogs after performing a pancreatectomy, that apart hyperglycemia and glycosuria (carbohydrate metabolism), had noted also changes in lipid and protein metabolism. "
4.	Transplantation 12/07/2018 - "Glycosuria was detected persistently during the first six months after transplantation. " 10/05/1991 - "Transient glycosuria and aminoaciduria in successful transplantation of infant kidneys to adults." 01/01/2017 - "Transplantation of wild-type bone marrow in Clcn5Y/- mice significantly improved proximal tubule dysfunction, with decreased low-molecular-weight proteinuria, glycosuria, calciuria, and polyuria four months after transplantation, compared to Clcn5Y/- mice transplanted with ClC-5 knockout bone marrow. " 02/01/2008 - "Three yr after transplantation she developed renal Fanconi syndrome with severe metabolic acidosis, hypophosphatemia, glycosuria, and aminoaciduria. " 09/01/1987 - "After transplantation of bone marrow plus newborn pancreas, NOD mice showed reduction of the glycosuria and a normal response in the glucose-tolerance test. "
5.	Denervation 10/01/2017 - "Hence, we conclude that ArcPomc is essential in maintaining basal RSNA and that elevated glycosuria is a possible mechanism to explain improved glucose tolerance after renal denervation in drug resistant hypertensive patients." 10/01/2017 - "Remarkably, both WT and db/db mice exhibited elevated glycosuria and improved glucose tolerance after renal denervation. "