Abstract |
The utility of a single high-dose (0.3 mmol/kg) injection of gadoteridol, a gadolinium chelate, in the detection of brain metastases on magnetic resonance images was studied. Patients (n = 29) with a high suspicion for brain metastases at clinical examination and by history were imaged on two occasions--separated by more than 24 hours and less than 7 days--with a 0.1 mmol/kg contrast agent dose used for the first study and a 0.3 mmol/kg dose for the second. In patients (n = 15) with confirmed brain metastases by clinical, radiologic, and/or histologic criteria, 40 lesions were detected at the 0.3 mmol/kg dose by a single reader blinded to contrast agent dose, compared with 33 lesions at 0.1 mmol/kg, a 21% increase. Three of 15 patients (20%) demonstrated an increase in the number of lesions detected at the higher dose. Region-of-interest analysis of signal intensity measurements showed that lesion contrast (relative to normal brain) improved from 54% at 0.1 mmol/kg to 92% at 0.3 mmol/kg. A 0.3 mmol/kg dose of gadoteridol, administered in a single injection, permits identification of brain metastases not detected at 0.1 mmol/kg. Such information can influence the choice of therapy.
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Authors | V M Runge, J W Wells, K L Nelson, P M Linville |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
1994 Sep-Oct
Vol. 4
Issue 5
Pg. 669-73
ISSN: 1053-1807 [Print] United States |
PMID | 7981511
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Contrast Media
- Heterocyclic Compounds
- Organometallic Compounds
- gadoteridol
- Gadolinium
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Brain Neoplasms
(diagnosis, secondary)
- Contrast Media
(administration & dosage)
- Gadolinium
(administration & dosage)
- Heterocyclic Compounds
(administration & dosage)
- Humans
- Image Enhancement
(methods)
- Magnetic Resonance Imaging
(methods)
- Middle Aged
- Organometallic Compounds
(administration & dosage)
- Prospective Studies
- Sensitivity and Specificity
- Single-Blind Method
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