Abstract | OBJECTIVE: To describe the hepatotoxicity associated with ingestion of the Chinese herbal product Jin Bu Huan Anodyne Tablets (Lycopodium, serratum) and to propose possible mechanisms of injury. DESIGN: Retrospective analysis. SETTING: Academic hepatology units and private practice facilities. PATIENTS: Seven previously healthy patients. MEASUREMENTS: Clinical, laboratory, radiologic, and histologic studies. RESULTS: CONCLUSION:
Jin Bu Huan can cause liver injury. Although the hepatotoxic mechanisms are not defined, they may include hypersensitive or idiosyncratic reactions or direct toxicity to active metabolites. Hepatotoxicity caused by herbal products underscores the toxicity caused by herbal products underscores the importance of national surveillance programs and quality control of the manufacture of these products.
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Authors | G M Woolf, L M Petrovic, S E Rojter, S Wainwright, F G Villamil, W N Katkov, P Michieletti, I R Wanless, F R Stermitz, J J Beck, J M Vierling |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 121
Issue 10
Pg. 729-35
(Nov 15 1994)
ISSN: 0003-4819 [Print] United States |
PMID | 7944049
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Acute Disease
- Adult
- Biopsy
- Chemical and Drug Induced Liver Injury
(diagnosis, etiology)
- Drugs, Chinese Herbal
(adverse effects, standards)
- Female
- Humans
- Liver Function Tests
- Male
- Middle Aged
- Quality Control
- Retrospective Studies
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