In vitro selective toxicity of toxin T-514 from Karwinskia humboldtiana (buckthorn) plant on various human tumor cell lines.

Abstract

Toxin T-514 is a dimeric anthracenone isolated from the Karwinskia humboldtiana (buckthorn) plant. Its potential anti-neoplastic effect was evaluated in vitro and the results obtained were compared with the effect of other known anti-cancer agents. Normal and malignant continuous cell lines were tested. After a 72-h exposure, neoplastic cells derived from hepatic, pulmonary and colonic tissues were more sensitive to toxin T-514 than normal cells from the corresponding organ. Hepatoma cells and colon adenocarcinoma CT50 values were < 10 micrograms/ml. Lung adenocarcinoma, undifferentiated bronchogenic cancer cells and small cell carcinoma CT50 values were < 20 micrograms/ml. All benign cell CT50 levels tested were > 113 micrograms/ml. This in vitro selective toxicity found with toxin T-514 was also seen with 5-fluororacil and mitomycin for colon adenocarcinoma and with epidoxorubicin for undifferentiated bronchogenic cancer cells.

• Authors: A Piñeyro-López, L Martínez de Villarreal, R González-Alanís
• Journal: Toxicology (Toxicology) Vol. 92 Issue 1-3 Pg. 217-27 (Sep 06 1994) ISSN: 0300-483X [Print] Ireland
• PMID: 7940562 (Publication Type: Journal Article)

Chemical References

• Anthracenes
• Antineoplastic Agents, Phytogenic
• Karwinskia toxin T-514

Topics

• Anthracenes (pharmacology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Cell Survival (drug effects)
• Cells, Cultured (drug effects)
• Colon (cytology)
• Colonic Neoplasms (drug therapy)
• Humans
• Liver (cytology)
• Liver Neoplasms (drug therapy)
• Lung (cytology)
• Lung Neoplasms (drug therapy)
• Tumor Cells, Cultured (drug effects)