Abstract |
Retinal pigment epithelium (RPE) cells migrating through the damaged retina play an important role in the pathogenesis of proliferative vitreoretinopathy (PVR). We found that alpha-tocopherol ( vitamin E) inhibits proliferation of human RPE in culture without exerting cytotoxic effects. Maximal inhibition was achieved with 100 microM alpha-tocopherol. Our result could explain the observation that vitamin E supplements have an adverse effect on light-damaged retina and on the course of retinitis pigmentosa. Since it has been shown that supplemental oral administrations of vitamin E can raise the RPE concentration of alpha-tocopherol well above 100 microM and supplementation is not associated with any clinical relevant adverse effect, we believe that vitamin E could be beneficial in the treatment of PVR.
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Authors | D Mojon, D Boscoboinik, A Haas, M Bohnke, A Azzi |
Journal | Ophthalmic research
(Ophthalmic Res)
Vol. 26
Issue 5
Pg. 304-9
( 1994)
ISSN: 0030-3747 [Print] Switzerland |
PMID | 7877801
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Cell Division
(drug effects)
- Cells, Cultured
- Humans
- Middle Aged
- Pigment Epithelium of Eye
(cytology, drug effects)
- Vitamin E
(pharmacology)
- Vitreoretinopathy, Proliferative
(drug therapy)
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