[Probucol treatment of hyperlipidemia].

Abstract

Probucol lowers total and LDL cholesterol levels, and also lowers HDL cholesterol levels. Probucol is able to lower cholesterol levels in homozygous patients with familial hypercholesterolemia as well as in heterozygous patients. In heterozygous familial hypercholesterolemia, probucol lowered total cholesterol levels by 22%, LDL-cholesterol levels by 17%, and HDL-cholesterol levels by 40%, respectively. The lowering HDL cholesterol levels by probucol may reflect increased reverse cholesterol transport. Probucol increases cholesteryl ester transfer protein concentration, and diminishes HDL particle size. Probucol has been reported to retard and even regress atherosclerosis in animal models and to diminish tendinous xanthomas in man. Its lowering LDL-cholesterol levels, activation of reverse cholesterol transport process, and antioxidant effects may cause an antiatherogenic action.

• Authors: J Koizumi
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 52 Issue 12 Pg. 3279-84 (Dec 1994) ISSN: 0047-1852 [Print] Japan
• PMID: 7853723 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• CETP protein, human
• Carrier Proteins
• Cholesterol Ester Transfer Proteins
• Cholesterol, HDL
• Cholesterol, LDL
• Glycoproteins
• Probucol

Topics

• Carrier Proteins
• Cholesterol Ester Transfer Proteins
• Cholesterol, HDL (metabolism)
• Cholesterol, LDL (metabolism)
• Female
• Glycoproteins
• Heterozygote
• Humans
• Hyperlipoproteinemia Type II (drug therapy, genetics)
• Male
• Probucol (pharmacology, therapeutic use)