Pulmonary fibrosis and myositis in a child with anti-Jo-1 antibody.

Abstract

This is the first report of a child with anti-Jo-1 antibody. At 10, she had a chronic cough, wheezing, dyspnea on exertion, a combined obstructive and restrictive ventilatory defect, and a decreased diffusion capacity compatible with alveolar fibrosis (lung biopsy). By age 12, she developed arthralgias, malar rash, frontal alopecia, Raynaud's phenomenon, and was seropositive for antinuclear antibodies, (SSA)Ro, Jo-1 and rheumatoid factor. At 16, symptomatic inflammatory myositis (elevated creatinine kinase, muscle biopsy) was documented with persistent anti-Jo-1. Her pulmonary symptoms have progressed despite appropriate therapy. Although her digits have become sausage shaped with swan neck deformities, joint pain is not frequent.

• Authors: J F Chmiel, H U Wessel, I N Targoff, L M Pachman
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 22 Issue 4 Pg. 762-5 (Apr 1995) ISSN: 0315-162X [Print] Canada
• PMID: 7791178 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies
• Histidine-tRNA Ligase

Topics

• Adolescent
• Adult
• Antibodies (analysis)
• Child
• Female
• Histidine-tRNA Ligase (immunology)
• Humans
• Myositis (complications, immunology)
• Pulmonary Fibrosis (complications, immunology)
• Respiration Disorders (etiology)