[The limitation of glucose catabolism as a factor in protection during hypoxia].

Abstract

Violuric acid was first shown to have antihypoxic and antioxidative properties, to exert protective action in sodium nitrite-induced hemic hypoxia. Hepatic glucose and glucogen levels increased, the activity of glucose-6- phosphodihydrogenase enhanced, while that of lactate dehydrogenase and alkaline phosphatase decreased, the content of cAMP restored, whereas cGMP and 2,3-diphosphoglycerate levels decreased to a greater extent. The action of violuric acid was especially evident at the ultrastructural level-the ultrastructure of brush receptor elements in anoxia in the presence of violuric acid's action retained all the features characteristic for intact animals, which was accompanied by a significant accumulation of glycogen in the neuroplasm.

• Authors: A T Burbello, V V Vishvtseva, P P Denisenko, A F Safonova, E G Dobrokhotova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 Jan-Feb Vol. 58 Issue 1 Pg. 49-52 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Ogranichenie katabolizma gliukozy kak faktor zashchity pri gipoksii.
• PMID: 7787699 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Barbiturates
• violuric acid
• Glucose
• Sodium Nitrite

Topics

• Animals
• Antioxidants (therapeutic use)
• Barbiturates (therapeutic use)
• Carbohydrate Metabolism
• Drug Evaluation, Preclinical
• Glucose (metabolism)
• Hypoxia (chemically induced, metabolism, pathology)
• Mitochondria (drug effects, ultrastructure)
• Rats
• Sodium Nitrite