[Alanine aminotransferase--a surrogate marker of viral hepatitis].

Abstract

Examinations of 4457 blood donors (about 80% were men aged 18 to 30) revealed an increased level of serum glutamic-pyruvic transaminase (SGPT) in 82 (1.8%). Specific markers of viral hepatitis C were detected in 15.9%, of hepatitis B in 12.0%, of hepatitis D in 2.0%, of hepatitis E in 8.0%, of hepatitis A in 2.0% of sera with high SGPT levels. Mandatory screening of blood donors revealed specific markers of viral hepatitis in 15.9% of cases, additional testing detected these markers in 10.9% cases more. A conclusion is made that an increase of SGPT activity is an independent surrogate marker of viral hepatitis.

• Authors: E B Zhiburt, N V Bel'gesov, T N Vashchenko, I G Bondarenko, V S Tokmakov, V B Vasiliuk
• Journal: Voprosy virusologii (Vopr Virusol) 1995 Jan-Feb Vol. 40 Issue 1 Pg. 25-7 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Alaninaminotransferaza--surrogatnyĭ marker virusnogo gepatita.
• PMID: 7740784 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Alanine Transaminase

Topics

• Adolescent
• Adult
• Alanine Transaminase (analysis)
• Biomarkers (analysis)
• Hepatitis (enzymology)
• Humans
• Male