Comparison of the haemodynamic effects of mivacurium and atracurium during fentanyl anaesthesia.

Abstract

We have measured the haemodynamic effects of mivacurium 0.15 and 0.2 mg kg-1, and atracurium 0.5 mg kg-1 administered over 10-15 s in patients undergoing coronary artery bypass surgery under fentanyl anaesthesia. There were no significant haemodynamic changes in the atracurium group, other than a transient decrease in pulmonary arterial wedge pressure. Changes in heart rate were small in all three groups. Mivacurium 0.15 mg kg-1 produced changes of only small magnitude (12% decrease in mean arterial pressure and 16% decrease in systemic vascular resistance index) however, mivacurium 0.2 mg kg-1 produced a 25% reduction in mean arterial pressure, a 14% increase in cardiac index and a 35% decrease in systemic vascular resistance index. Erythema developed in two, three and seven patients after atracurium, mivacurium 0.15 mg kg-1 and mivacurium 0.2 mg kg-1, respectively. One patient exhibited a 54% decrease in mean arterial pressure, generalized erythema and bronchospasm after mivacurium 0.2 mg kg-1. The haemodynamic changes with mivacurium suggested histamine release.

• Authors: P B Loan, P Elliott, R K Mirakhur, H F Bunting, S Bhanumurthy, T J McMurray
• Journal: British journal of anaesthesia (Br J Anaesth) Vol. 74 Issue 3 Pg. 330-2 (Mar 1995) ISSN: 0007-0912 [Print] England
• PMID: 7718382 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Isoquinolines
• Neuromuscular Depolarizing Agents
• Atracurium
• Mivacurium
• Fentanyl

Topics

• Atracurium (pharmacology)
• Blood Pressure (drug effects)
• Cardiac Output (drug effects)
• Coronary Artery Bypass
• Drug Administration Schedule
• Erythema (chemically induced)
• Fentanyl
• Hemodynamics (drug effects)
• Humans
• Isoquinolines (pharmacology)
• Mivacurium
• Neuromuscular Depolarizing Agents (pharmacology)
• Vascular Resistance (drug effects)