Abstract |
Although chemotherapeutic agents are widely used in the treatment of cancer, few experimental data are available on their effects on host N metabolism. We studied the effects of a single intraperitoneal (IP) injection of cyclophosphamide ([CYP] 120 mg/kg), 5-fluorouracil ([5-FU], 50 mg/kg), cisplatinum ([CDDP], 5 mg/kg), or methotrexate ([MTX], 30 mg/kg). N balance was studied for 6 days following chemotherapy in healthy rats (n = 40) and in rats bearing Morris Hepatoma 7777 ([MH7777] n = 40) in a situation comparable to that of human cancer ( tumor burden < 0.2% of body weight, moderate anorexia, and weight loss). In healthy rats, all drugs induced transient body weight loss, anorexia, and poor N balance. At day 6 posttreatment, all animals had resumed normal feed intake and positive N balance except CDDP-treated rats, which showed continued weight loss and poor N balance. CDDP and MTX exhibited antitumor activity; however, CDDP induced diarrhea in six of eight tumor-bearing rats. Drug-induced anorexia was more severe in tumor-bearing than in healthy treated rats. N balance was more severely decreased in MH7777-bearing rats than in healthy treated animals in response to 5-FU (159 +/- 36 v 273 +/- 27 mg N/2 d) and MTX (-66 +/- 36 v 153 +/- 37 mg N/2 d) at days 3 to 4 postinjection. These results establish the presence of drug-specific effects on host N balance and the existence of a drug- tumor interaction for N metabolism in the tumor-bearing host.
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Authors | T Le Bricon, S Gugins, L Cynober, V E Baracos |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 44
Issue 10
Pg. 1340-8
(Oct 1995)
ISSN: 0026-0495 [Print] United States |
PMID | 7476295
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Proteins
- RNA
- Cyclophosphamide
- DNA
- Nitrogen
- Cisplatin
- Fluorouracil
- Methotrexate
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Topics |
- Animals
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Cachexia
(chemically induced, metabolism, physiopathology)
- Cisplatin
(adverse effects, therapeutic use)
- Cyclophosphamide
(adverse effects, therapeutic use)
- DNA
(analysis, metabolism)
- Eating
(drug effects, physiology)
- Female
- Fluorouracil
(adverse effects, therapeutic use)
- Intestine, Small
(chemistry, metabolism, pathology)
- Liver
(drug effects, metabolism, pathology)
- Liver Neoplasms, Experimental
(drug therapy, metabolism, physiopathology)
- Methotrexate
(adverse effects, therapeutic use)
- Muscle, Skeletal
(chemistry, metabolism, pathology)
- Nitrogen
(analysis, metabolism, urine)
- Organ Size
- Proteins
(metabolism)
- RNA
(analysis, metabolism)
- Rats
- Rats, Sprague-Dawley
- Weight Loss
(physiology)
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