Effects of synthetic parathyroid hormone on vascular beds of dogs.

Abstract

Blood flow rates and vascular resistance in dogs were determined in 14 tissues with 15 +/- 2 microns radioactive microspheres (141Ce, 51Cr, 85Sr). Intravenous injections of synthetic bovine parathyroid hormone containing the NH2-terminal 1--34 amino acids [bPTH-(1--34)] at the dose of 10 USP units/kg body weight produced hypotension and increases in blood flow rate and decreases in resistance in kidney cortex, kidney medulla, heart, liver, stomach and pancreas at 1/2 and 2 min after injection. 4 U bPTH-(1--34)/kg body weight produced less vasodilation. Saline injection had no effect on the tissues studied.

• Authors: P K Pang, H F Janssen, J A Yee
• Journal: Pharmacology (Pharmacology) Vol. 21 Issue 3 Pg. 213-22 ( 1980) ISSN: 0031-7012 [Print] Switzerland
• PMID: 7413722 (Publication Type: Journal Article)

Chemical References

• Parathyroid Hormone

Topics

• Animals
• Blood Pressure (drug effects)
• Dogs
• Female
• Male
• Parathyroid Hormone (pharmacology)
• Regional Blood Flow (drug effects)
• Vascular Resistance (drug effects)