HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome.

Abstract

In a study designed to confirm our preliminary report of associations between HLA-B12, atopy, and relapse following cyclophosphamide treatment in steroid-responsive nephrotic syndrome (SRNS), we again found a higher incidence of HLA-B12 in SRNS children (44%) than we did in controls (24%). The association of HLA-B12 with short time-to-relapse after cyclophosphamide treatment of SRNS was also confirmed, but that with atopy in SRNS children was not, though we observed a similarly high incidence of atopy in them as before.

• Authors: R S Trompeter, T M Barratt, R Kay, M W Turner, J F Soothill
• Journal: Kidney international (Kidney Int) Vol. 17 Issue 1 Pg. 113-7 (Jan 1980) ISSN: 0085-2538 [Print] United States
• PMID: 7374015 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• Immunoglobulin E
• Cyclophosphamide

Topics

• Asthma (immunology)
• Child
• Cyclophosphamide (therapeutic use)
• Eczema (immunology)
• HLA Antigens
• Humans
• Hypersensitivity, Immediate (immunology)
• Immunoglobulin E (metabolism)
• Nephrotic Syndrome (drug therapy, immunology)
• Recurrence
• Rhinitis, Allergic, Seasonal (immunology)
• Skin Tests
• Time Factors