Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology.

Abstract

Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.

• Authors: J Fishman, C Martucci
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 51 Issue 3 Pg. 611-5 (Sep 1980) ISSN: 0021-972X [Print] United States
• PMID: 7190977 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Estrogens
• Hydroxyestrones
• Receptors, Estrogen
• Sex Hormone-Binding Globulin
• 16-hydroxyestrone
• Estrone
• Estradiol
• Luteinizing Hormone
• Estriol

Topics

• Animals
• Castration
• Estradiol (metabolism)
• Estriol (metabolism)
• Estrogens (pharmacology, physiology)
• Estrone (analogs & derivatives)
• Female
• Hydroxyestrones (pharmacology)
• Luteinizing Hormone (blood)
• Rats
• Receptors, Estrogen (metabolism)
• Sex Hormone-Binding Globulin (metabolism)
• Uterus (drug effects, metabolism)