Abstract |
Elevated plasma renin activity was found in 6 out of 7 essential hypotensive patients. This was taken to reflect some abnormality in sodium handling, and they were treated with synthetic calcium glycyrrhetinyl-glycinate (G.G.), a water soluble derivative of glycyrrhetinic acid which was derived from licorice. G.G. was administrated in doses of 300 mg to 1200 mg daily for 3 to 9 weeks. Both the systolic (25.8 +/- 10.0 mmHg) and diastolic (19.2 +/- 9.8 mmHg) blood pressure successfully elevated and improvement or resolution of clinical symptoms was noted in 6 patients. Marked suppression in plasma renin activity (2.7 +/- 1.2 ng/ml/hr) and plasma aldosterone concentration (8.1 +/- 3.1 ng/100 ml) with mild reduction in serum potassium concentration (1.0 +/- 0.4 mEq/L) were concomitantly observed. One patient did not respond at all to G.G. Adverse reactions were mild in all but one who had frank edema.
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Authors | M Imagawa, H Kamei, K Arakawa |
Journal | Japanese heart journal
(Jpn Heart J)
Vol. 23
Issue 2
Pg. 201-9
(Mar 1982)
ISSN: 0021-4868 [Print] Japan |
PMID | 7043023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- glycyrrhetinyl-glycine conjugate
- Renin
- Glycyrrhetinic Acid
- Potassium
- Glycine
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Topics |
- Adult
- Blood Pressure
(drug effects)
- Female
- Glycine
(therapeutic use)
- Glycyrrhetinic Acid
(therapeutic use)
- Humans
- Hypotension
(blood, drug therapy, physiopathology)
- Male
- Middle Aged
- Potassium
(blood)
- Renin
(blood)
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