A comparison of phenelzine and imipramine in depressed inpatients.

Abstract

Phenelzine and imipramine were compared double-blind, in 43 depressed inpatients. A placebo week preceded drug treatment; this allowed early identification of placebo responders who did not therefore enter the study. After three weeks treatment, the two drugs were equally effective on Hamilton, Beck and SCL-90 measures of depression and anxiety. On the the SCL-90 scales of hostility and paranoia imipramine was more effective; in some patients phenelzine was associated with increased hostility. Measurement of MAO inhibition and plasma tricyclic levels indicated that adequate doses were generally used - (mean 81 mg/day phenelzine and 144 mg/day imipramine).

• Authors: J R Davidson, M N McLeod, C D Turnbull, R D Miller
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 42 Issue 10 Pg. 395-7 (Oct 1981) ISSN: 0160-6689 [Print] United States
• PMID: 7026542 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Phenelzine
• Imipramine

Topics

• Adult
• Clinical Trials as Topic
• Depressive Disorder (drug therapy)
• Double-Blind Method
• Female
• Humans
• Imipramine (therapeutic use)
• Male
• Phenelzine (therapeutic use)
• Random Allocation