Fluproquazone: analgesic activity in outpatients with non-migrainous headache.

Abstract

The analgesic activity of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) was investigated in three separate controlled studies including 131 outpatients with non-migrainous headache. By means of the patients' self-assessment of pain intensity and pain relief, 25 mg and 50 mg doses were shown to be effective according to some parameters of analgesic effect; a 100-mg dose was more effective, being significantly different from placebo for all parameters of analgesia. Fluproquazone 50 mg was as active as acetylsalicylic acid 1000 mg and slightly less active than a combination of propyphenazone 220 mg and allobarbital 30 mg. Except for the occurrence of vomiting in one patient after fluproquazone 50 mg and 100 mg. the drug was well tolerated.

• Authors: A J Wood, B von Graffenried
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 31 Issue 5a Pg. 914-7 ( 1981) ISSN: 0004-4172 [Print] Germany
• PMID: 7023493 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Analgesics
• Placebos
• Quinazolines
• Quinazolinones
• Aspirin
• fluproquazone

Topics

• Adult
• Aged
• Analgesics
• Aspirin (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Headache (drug therapy)
• Humans
• Male
• Middle Aged
• Placebos
• Quinazolines (therapeutic use)
• Quinazolinones
• Time Factors