Carbenoxolone patients with gastric ulcers. A double-blind trial.

Abstract

Carbenoxolone was compared with placebo in a randomised double-blind study involving 40 patients with gastric ulcer (20 each in the treated and placebo groups). The evaluation was based on eight variables. The endoscopic findings on completion of 4 or 6 weeks of treatment, revealed greater improvement in response to carbenoxolone than to placebo. The difference was statistically significant at the previously fixed level of significance of p less than 0.05. The plasma potassium level fell significantly in the treated group but the actual reduction of 7% was slight. No statistically significant differences were measured in any of the other variables, i.e. plasma sodium, SGOT, SGPT, systolic and diastolic blood pressure, bodyweight, or oedema formation.

• Authors: K Schwamberger, H Reissigl
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 65 Pg. 59-62 ( 1980) ISSN: 0085-5928 [Print] England
• PMID: 7010529 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Carbenoxolone
• Glycyrrhetinic Acid
• Potassium

Topics

• Adult
• Body Weight (drug effects)
• Carbenoxolone (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Edema (chemically induced)
• Female
• Gastroscopy
• Glycyrrhetinic Acid (analogs & derivatives)
• Humans
• Male
• Potassium (blood)
• Random Allocation
• Stomach Ulcer (drug therapy)