[Effect of intravenous prostaglandin E2 administration on central hemodynamics in ischemic heart disease patients].

Abstract

A total of 27 patients were examined: 12 of them had non-coronarogenic cardialgias and 15 had ischemic heart disease. Prostaglandin E2 intravenous infusion followed the coronary angiography and ventriculography against the background of stabilized pressure in the left ventricle. The infusion lasted 10 minutes, then ventriculography was repeated. The total dose of prostaglandin E2 was 0.5-1.5 mg. Prostaglandin E2 had positive chronotropic and inotropic effects, as well as hypotensive and venodilatative ones. Stroke volume was decreased in most observations. Prostaglandin E2 eliminated the attacks of cardiac asthma and angina pectoris, caused by the increase of the left ventricle cavity.

• Authors: A A Agapov
• Journal: Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR (Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR) Vol. 5 Issue 1 Pg. 86-8 ( 1982) ISSN: 0201-7369 [Print] Russia (Federation)
• Vernacular Title: Vliianie vnutrivennogo vvedeniia prostaglandina E2 na tsentral'nuiu gemodinamiku u bol'nykh IBS.
• PMID: 6953970 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Prostaglandins E
• Dinoprostone

Topics

• Coronary Disease (drug therapy, physiopathology)
• Diastole (drug effects)
• Dinoprostone
• Drug Evaluation
• Heart Rate (drug effects)
• Heartburn (drug therapy, physiopathology)
• Hemodynamics (drug effects)
• Humans
• Prostaglandins E (administration & dosage)
• Systole (drug effects)