Failure of oral versus parenteral corticosteroids in a case of acute inflammatory polyradiculoneuropathy (Guillain-Barré syndrome).

Abstract

A case of acute inflammatory polyradioculoneuropathy (IPN, Guillain-Barré syndrome) not responding to oral corticosteroids but showing marked improvement on parenteral corticosteroids is reported. Oral prednisone 60 mg/day was begun on hospital admission and increased after one week to 100 mg/day; however, the patient's respiratory function, demonstrated by forced vital capacity, continued to deteriorate. Improvement was noted when the patient was switched to intravenous methyl-prednisolone 100 mg/day. Further attempts to use oral corticosteroids (including oral methyl-prednisolone 96 mg/day) resulted in deterioration of the patient's function.

• Authors: R A Brumback
• Journal: Australian and New Zealand journal of medicine (Aust N Z J Med) Vol. 10 Issue 2 Pg. 224-6 (Apr 1980) ISSN: 0004-8291 [Print] Australia
• PMID: 6930216 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisolone
• Methylprednisolone

Topics

• Administration, Oral
• Adolescent
• Biological Availability
• Humans
• Infusions, Parenteral
• Male
• Methylprednisolone (administration & dosage, metabolism)
• Polyradiculoneuropathy (drug therapy)
• Prednisolone (administration & dosage, metabolism)