Intracranial pressure after phenoperidine.

Abstract

The problem of sedating patients requiring prolonged controlled ventilation has recently received considerable attention. Various therapeutic regimes are available and there appears to be a general move away from the use of muscle relaxants towards sedative drugs. Phenoperidine is a popular agent for this purpose. One survey from a district general hospital reported that 66% of their ventilated intensive therapy unit patients received phenoperidine, either alone or as part of a sedation regime. However, enthusiasm for its use must be tempered by recent reports of cardiovascular collapse following its administration. We wish to report a case of intracranial hypertension following the use of phenoperidine in a ventilated patient with a severe head injury.

• Authors: R M Grummitt, V A Goat
• Journal: Anaesthesia (Anaesthesia) Vol. 39 Issue 6 Pg. 565-7 (Jun 1984) ISSN: 0003-2409 [Print] England
• PMID: 6742389 (Publication Type: Case Reports, Journal Article)

Chemical References

• Phenoperidine

Topics

• Blood Pressure (drug effects)
• Craniocerebral Trauma
• Critical Care
• Female
• Humans
• Intracranial Pressure (drug effects)
• Middle Aged
• Phenoperidine (adverse effects)
• Respiration, Artificial