The effects of 9-hydroxy-19,20-bis-norprostanoic acid on mucus, acid and gastrin secretion in duodenal ulcer patients.

Abstract

The effects of 9-hydroxy-19,20-bis norprostanoic acid (rosaprostol, IBI), a new prostaglandin analogue, on gastric secretion and gastrin release were studied in 15 patients with duodenal ulcer. In acute experiments, rosaprostol lowered pentagastrin-stimulated acid secretion by 27-36%, whereas after chronic administration there were no changes in acid secretion or gastrin release (fasting and oxo-stimulated) but N-acetylneuraminic acid (NANA)-glycoproteins increased significantly. Our results indicate that the antisecretory and mucopoietic activities of 9-hydroxy-19,20-bis-norprostanoic acid are the basis of its healing effect in duodenal ulcer patients.

• Authors: D Foschi, F Ferrante, F Callioni, A Bastagli, V Rovati
• Journal: Prostaglandins, leukotrienes, and medicine (Prostaglandins Leukot Med) Vol. 15 Issue 2 Pg. 147-52 (Aug 1984) ISSN: 0262-1746 [Print] Scotland
• PMID: 6593741 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Fatty Acids
• Gastrins
• Prostanoic Acids
• rosaprostol

Topics

• Adolescent
• Adult
• Aged
• Anti-Ulcer Agents (therapeutic use)
• Duodenal Ulcer (drug therapy, physiopathology)
• Fatty Acids (therapeutic use)
• Gastric Acid (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Gastrins (metabolism)
• Humans
• Male
• Middle Aged
• Prostanoic Acids (therapeutic use)