Effect of indomethacin on postsurgical edema in rats.

Abstract	The effectiveness of intramuscular indomethacin was compared with that of hydrocortisone succinate for the control of edema resulting from experimentally induced surgical trauma in rats. Both drugs produced a significant reduction in tissue water, but no difference could be detected between the effects of the two drugs. These findings indicate the advisability of clinical trials of indomethacin in the control of postsurgical swelling and pain.
Authors	M M Amin, M B Engel, D M Laskin
Journal	Oral surgery, oral medicine, and oral pathology (Oral Surg Oral Med Oral Pathol) Vol. 55 Issue 3 Pg. 244-6 (Mar 1983) ISSN: 0030-4220 [Print] United States
PMID	6572877 (Publication Type: Comparative Study, Journal Article)
Chemical References	hydrocortisone hemisuccinate Hydrocortisone Indomethacin
Topics	Animals Edema (prevention & control) Hydrocortisone (administration & dosage, analogs & derivatives, therapeutic use) Indomethacin (administration & dosage, therapeutic use) Injections, Intramuscular Male Postoperative Complications (prevention & control) Rats Rats, Mutant Strains

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