Fluorometholone acetate: clinical evaluation in the treatment of external ocular inflammation.

Abstract

Separate, randomized, double-masked clinical studies were conducted to determine the therapeutic efficacy of fluorometholone acetate, a new ophthalmic corticosteroid formulation, in suppressing external ocular inflammation (conjunctivitis, episcleritis, scleritis). Fluorometholone acetate 0.1% was compared to fluorometholone 0.1%, and the acetate formulation was found to be significantly (p = 0.03) more effective. Fluorometholone acetate 0.1% also was compared to prednisolone acetate 1.0%; there was no significant difference (p = 0.49) between these two corticosteroids in their ability to suppress external ocular inflammation. It appears that alteration of fluorometholone from its alcohol base to its acetate derivative changes the drug from a moderately effective to a highly effective anti-inflammatory agent.

• Authors: H M Leibowitz, R A Hyndiuk, C Lindsey, A L Rosenthal
• Journal: Annals of ophthalmology (Ann Ophthalmol) Vol. 16 Issue 12 Pg. 1110-5 (Dec 1984) ISSN: 0003-4886 [Print] United States
• PMID: 6398026 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• prednisolone acetate
• Prednisolone
• Fluorometholone

Topics

• Adult
• Clinical Trials as Topic
• Conjunctivitis (drug therapy)
• Double-Blind Method
• Eye Diseases (drug therapy)
• Female
• Fluorometholone (therapeutic use)
• Humans
• Inflammation (drug therapy)
• Male
• Prednisolone (analogs & derivatives, therapeutic use)
• Random Allocation