Glutamine synthetase activity of muscle in acidosis.

Abstract

Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.

• Authors: P A King, L Goldstein, E A Newsholme
• Journal: The Biochemical journal (Biochem J) Vol. 216 Issue 2 Pg. 523-5 (Nov 15 1983) ISSN: 0264-6021 [Print] England
• PMID: 6140920 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dexamethasone
• Glutamate-Ammonia Ligase

Topics

• Acidosis (enzymology)
• Animals
• Dexamethasone (pharmacology)
• Diabetic Ketoacidosis (enzymology)
• Glutamate-Ammonia Ligase (metabolism)
• Kinetics
• Male
• Muscles (drug effects, enzymology)
• Rats
• Rats, Inbred Strains
• Starvation (enzymology)