Effect of aceclidine(+) isomer and pilocarpine on the intraocular pressure decrease and the miosis in glaucomatous eyes. Effect on accommodation in normal eyes of young subjects.

Abstract	Previous studies demonstrated that the (+) isomer of aceclidine has a stronger cholinergic effect than pilocarpine or the racemic mixture of aceclidine. The effect of aceclidine(+) and pilocarpine on the intraocular pressure and the sphincter pupillae in patients suffering from open angle glaucoma, and on the accommodation in normal young subjects, was studied. The results demonstrated a similar effect of both drugs. The discrepancy between the cholinergic potential of the drugs and their effect in the eye is discussed.
Authors	G Keren, G Treister
Journal	Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde (Ophthalmologica) Vol. 180 Issue 4 Pg. 181-7 ( 1980) ISSN: 0030-3755 [Print] Switzerland
PMID	6108545 (Publication Type: Comparative Study, Journal Article)
Chemical References	Parasympathomimetics Quinuclidines Pilocarpine
Topics	Accommodation, Ocular (drug effects) Adult Aqueous Humor (physiology) Glaucoma (drug therapy) Humans Intraocular Pressure (drug effects) Middle Aged Parasympathomimetics Pilocarpine (pharmacology, therapeutic use) Pupil (drug effects) Quinuclidines (pharmacology, therapeutic use) Stereoisomerism

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