Leukotriene C5: a slow reacting substance derived from eicosapentaenoic acid.

Abstract

Mouse mastocytoma cells incubated with ionophore A23187 and eicosapentaenoic acid (n-3) produced a slow reacting substance with different properties compared with leukotriene C4 (previously designated leukotriene C). This product was characterized by spectroscopy and enzymatic and chemical degradations to be 5-hydroxy-6-S-glutathionyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene C5). Leukotriene C5 has similar biological activity on the isolated guinea pig ileum but is less potent than is leukotriene C4.

• Authors: S Hammarström
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 255 Issue 15 Pg. 7093-4 (Aug 10 1980) ISSN: 0021-9258 [Print] United States
• PMID: 6104669 (Publication Type: Journal Article)

Chemical References

• Eicosanoic Acids
• Fatty Acids, Unsaturated
• SRS-A
• leukotriene C-5
• Eicosapentaenoic Acid
• Lipoxygenase
• gamma-Glutamyltransferase

Topics

• Animals
• Biological Assay
• Cell Line
• Chromatography, High Pressure Liquid
• Eicosanoic Acids (biosynthesis, metabolism)
• Eicosapentaenoic Acid
• Fatty Acids, Unsaturated (biosynthesis, metabolism)
• Guinea Pigs
• Ileum (drug effects)
• Kidney (enzymology)
• Lipoxygenase (metabolism)
• Mast-Cell Sarcoma (metabolism)
• Mice
• Plants (enzymology)
• SRS-A (analogs & derivatives)
• gamma-Glutamyltransferase (metabolism)