Adverse reactions to practolol in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program.

Abstract

Adverse reactions to practolol were studied in 198 prospectively monitored hospitalized medical patients. The mean age of the practolol recipients was 57 years; angina and cardiac arrhythmias were the most common indications for therapy. Adverse reactions were attributed to practolol in 20 patients (10%). Fifteen of these twenty reactions involved impairment of cardiac function (bradyarrhythmias, heart block, congestive heart failure, hypotension), and in three instances the reaction was considered life-threatening. Three additional patients had cutaneous reactions attributed to the drug. Adverse reactions to practolol were not dose-related, but toxicity appeared to be more frequent among patients concurrently receiving quinidine. The frequency of cardiovascular complications of propranolol in a similar series of patients was nearly identical. However, no skin reactions were attributed to propranolol. The findings suggest that practolol and propranolol produce unwanted cardiovascular effects with nearly equal frequency among hospitalized patients. Cutaneous reactions to practolol are evident even during short-term use.

• Authors: H J Pfeifer, D J Greenblatt, J Koch-Weser
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 12 Issue 3 Pg. 167-70 (Nov 14 1977) ISSN: 0031-6970 [Print] Germany
• PMID: 590302 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Digitalis Glycosides
• Quinidine
• Practolol

Topics

• Aged
• Cardiovascular Diseases (chemically induced)
• Digitalis Glycosides (adverse effects)
• Drug Interactions
• Female
• Humans
• Male
• Middle Aged
• Practolol (adverse effects)
• Quinidine (adverse effects)