Proparathyroid hormone: biosynthesis by human parathyroid adenomas.

Abstract

Biosynthesis of a precursor (proparathyroid hormone) to human parathyroid hormone was demonstrated during incubation of tissue from parathyroid adenomas. The proparathyroid hormone is labeled more rapidly than parathyroid hormone during incubation with amino acids labeled with carbon-14 and is progressively converted to the hormone. Apparent differences in the relative rate of conversion of precursor to hormone found in different tumors suggest that proparathyroid hormone may accumulate in some of the tumors and be secreted into the circulation.

• Authors: J F Habener, B Kemper, J T Potts Jr, A Rich
• Journal: Science (New York, N.Y.) (Science) Vol. 178 Issue 4061 Pg. 630-3 (Nov 10 1972) ISSN: 0036-8075 [Print] United States
• PMID: 5086399 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Carbon Isotopes
• Parathyroid Hormone
• Protein Precursors

Topics

• Adenoma (metabolism)
• Amino Acids (metabolism)
• Animals
• Carbon Isotopes
• Cattle
• Electrophoresis, Polyacrylamide Gel
• Humans
• Hyperplasia (metabolism)
• Parathyroid Glands (metabolism)
• Parathyroid Hormone (analysis, biosynthesis)
• Parathyroid Neoplasms (metabolism)
• Protein Precursors (analysis, biosynthesis)
• Radioimmunoassay