A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression.

Abstract	A double-blind trial was undertaken to compare the antidepressant efficacy and the side effects of Lofepramine with those of Amitriptyline in the treatment of endogenous depression. The study involves 22 acutely ill endogenously depressive patients. 11 patients were treated with Lofepramine and the remaining 11 with Amitriptyline. The results demonstrate that both substances are effective in the treatment of depression. However, the therapeutical efficacy of Lofepramine is significantly greater than that of Amitriptyline. Furthermore, the tolerance of Lofepramine is better than that of Amitriptyline, and the side effects of Amitriptyline, especially in blood pressure dysregulation, are greater than those of Lofepramine.
Authors	A Marneros, M Philipp
Journal	International pharmacopsychiatry (Int Pharmacopsychiatry) Vol. 14 Issue 5 Pg. 300-4 ( 1979) ISSN: 0020-8272 [Print] Switzerland
PMID	395129 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References	Dibenzazepines Amitriptyline Lofepramine
Topics	Adult Aged Amitriptyline (adverse effects, therapeutic use) Clinical Trials as Topic Depression (drug therapy) Dibenzazepines (therapeutic use) Double-Blind Method Electrocardiography Female Humans Lofepramine (adverse effects, therapeutic use) Male Middle Aged Psychiatric Status Rating Scales

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