HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics.

Abstract

A series of diabetic patients from 3 centres in South India have been tested for HLA A, HLA B, BF, C2, C4A, C4B and GLO types. For insulin-dependent diabetes mellitus (IDDM) patients there was a significant increase in HLA B8, of BF F and decrease of C4 A6. No significant variation in HLA, BF, C2 or GLO frequencies was found in non-insulin-dependent diabetes mellitus (NIDDM) patients, but there was a significant decrease in C4B 1 and an increase in C4B 2. The HLA and BF association in South Indian IDDM patients is very different from that reported previously in North India.

• Authors: R L Kirk, P R Ranford, S W Serjeantson, A R Thompson, S M Munirathnam Chetty, L John, V Mohan, A Ramachandran, C Snehalatha, M Viswanathan
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 1 Issue 1 Pg. 41-7 (Mar 1985) ISSN: 0168-8227 [Print] Ireland
• PMID: 3879724 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Complement C2
• Complement C4
• Enzyme Precursors
• HLA Antigens
• HLA-A Antigens
• HLA-B Antigens
• Complement C4a
• Complement C4b
• Complement Factor B
• Lyases
• Lactoylglutathione Lyase

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Chromosomes, Human, 6-12 and X
• Complement C2 (analysis, genetics)
• Complement C4 (analysis, genetics)
• Complement C4a
• Complement C4b
• Complement Factor B (genetics)
• Diabetes Mellitus, Type 1 (epidemiology, genetics, immunology)
• Diabetes Mellitus, Type 2 (epidemiology, genetics, immunology)
• Enzyme Precursors (genetics)
• Gene Frequency
• HLA Antigens (analysis)
• HLA-A Antigens
• HLA-B Antigens
• Humans
• India
• Infant
• Infant, Newborn
• Lactoylglutathione Lyase (genetics)
• Lyases (genetics)
• Phenotype