Purpose: To evaluate the effectiveness of
rabeprazole and other
proton pump inhibitors (PPIs) in providing symptomatic relief in patients with varying severity of
gastroesophageal reflux disease (
GERD). Methods: In this multicenter retrospective study, electronic medical records (EMRs) of
GERD patients prescribed with PPIs at two Indian clinics/hospitals were reviewed (2016-2020).
Rabeprazole's effectiveness was assessed at different follow-up visits and compared with other PPIs. Results: Overall, 269 patients (moderate and severe
GERD: 84.39%) were included in three groups, viz
rabeprazole,
pantoprazole, and
esomeprazole groups. A significant proportion of patients experienced quick and complete symptomatic relief at visit 1 with
rabeprazole compared to the baseline visit, which gradually increased till visit 4 for both daytime [viz
heartburn (38.78-93.88%; p < 0.001)] and nocturnal symptoms [viz sleep disturbances (62.92-97.75%; p < 0.001)].
Rabeprazole provided quick relief at visit 1 when compared with
pantoprazole for daytime
heartburn (38.78 vs 5.56%; p = 0.01), daytime epigastric
pain (66.04 vs 12.12%; p = 0.049), and nocturnal water brash (60.71 vs 16.13%; p = 0.015), and when compared with
esomeprazole for nocturnal
nausea (82.61 vs 20.00%; p = 0.013). Further, the proportion of patients exhibiting complete treatment response was relatively higher in the
rabeprazole group (83.33%) than in the
pantoprazole (62.07%) and
esomeprazole (65.67%) groups at visit 4. Conclusion:
Rabeprazole was effective in providing quick and sustained relief for both daytime and nocturnal
GERD symptoms in patients with moderate and severe
GERD.
Rabeprazole also demonstrated greater effectiveness when compared with
pantoprazole and
esomeprazole in reducing the severity of multiple
GERD symptoms. How to cite this article: Lawate P, Jilawar N, Vyas K, et al. Effectiveness of
Rabeprazole and Other
Proton Pump Inhibitors in Managing
GERD with Varying Severity: A Retrospective, Real-world EMR-based Study (POWER
GERD Study). J Assoc Physicians India 2023;71(10):37-44.