Target identification is a crucial process in
drug development, aiming to identify key
proteins, genes, and signal pathways involved in
disease progression and their relevance in potential therapeutic interventions. While
C-C chemokine receptor 8 (CCR8) has been investigated as a candidate anti-
cancer target, comprehensive multi-omics analyzes across various indications are limited. In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-
cancer drug target. Our approach encompassed data collection from diverse knowledge resources, gene function analysis, differential gene expression profiling, immune cell infiltration assessment, and strategic prioritization of target indications. Our findings revealed strong correlations between CCR8 and specific
cancers, notably Breast Invasive
Carcinoma (BRCA),
Colon Adenocarcinoma (
COAD),
Head and Neck Squamous Cell Carcinoma (HNSC), Rectum
adenocarcinoma (READ), Stomach
adenocarcinoma (STAD), and
Thyroid carcinoma (THCA). This research advances our understanding of CCR8 as a potential target for anti-
cancer drug development, bridging the gap between molecular insights and creating opportunities for personalized treatment of solid
tumors.